Irf4 b cell

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August undefined, 2024

WebDec 10, 2024 · IRF4 is implicated in B cell malignancies, acting both as tumor suppressor and as tumor oncogene in different types of precursors and mature B cell neoplasia. Here, we summarize the complexity of IRF4 functions related to different DNA-binding affinity, multiple IRF4-specific target DNA motif, and interactions with transcriptional partners. WebIRF4. Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene, [5] [6] [7] located at 6p25-p23. IRF4 functions as a key regulatory transcription factor in the development of human immune cells. [8] [9] The expression of IRF4 is essential for the differentiation of T lymphocytes and B ...

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WebWe demonstrate that STAT3 is a critical transcriptional regulator of the activated B cell–like subtype of diffuse large B cell lymphoma (ABC DLBCL), the most common, aggressive, non-Hodgkin lymphoma. By genome-wide assessment, … WebJan 20, 2024 · The transcription factor interferon regulatory factor 4 (IRF4) is critical for development of the immune system, especially B and T cells. The IRF4 International Consortium identified seven patients from six … i mean nothing to you quotes

IRF4 - Wikipedia

WebMay 31, 2024 · Irf4/8 double-knockout mice show arrested B cell development at the cycling pre–B cell stage, with absence of immature IgM + B cells and high levels of pre-BCR expression ( Lu et al., 2003 ). Molecularly, both Irf4 and 8 induce germline transcription and promote L chain rearrangement and transcription ( Ma et al., 2008 ). WebDec 1, 2015 · IRF4 is an unusual component of the activated B cell gene-regulatory network, as it is an obligate controller of opposing cellular states and has been proposed to do this … WebAug 13, 2024 · Abstract Interferon regulatory factor 4 (IRF4) is a lymphoid transcription factor and a key regulator in the development of various immune cells, including T and B … i mean it\u0027s alright like 1 hour

IRF4 drives clonal evolution and lineage choice in a zebrafish

Translocations activating IRF4 identify a subtype of germinal …

WebApr 8, 2024 · IRF4 works in a dose-dependent manner in B cells, at low levels triggering the expression of the enzyme activation-induced deaminase (AID), thus driving somatic hypermutation and class switch recombination, and at high levels allowing the expression of Blimp-1 ( 21, 27 ), therefore being crucial for PC differentiation. WebNov 14, 2024 · One potential candidate transcription factor is interferon regulatory factor 4 (IRF4), which controls the differentiation of B, T, dendritic, and myeloid cells in a context … list of natural numberWebIrf4 -/-/Irf8 -/-B cells are hyperprolif-erative and fail to induce expression of the Ikaros family factors (Ikaros and Ai- olos) ( Ma et al., 2008). The IRF4 expression is induced by... list of natural hair colors

"WebApr 11, 2024 · A notable characteristic of type 2 immunity is that the initiation of the allergic response requires repeated exposures to the allergen. This contrasts with type 1 immunity, where a single infection is sufficient to drive a full-fledged immune response. One possible reason for this difference is that microbial antigens “replicate ... " - Irf4 b cell

Irf4 b cell

The dynamic functions of IRF4 in B cell malignancies

WebThe transcriptome of DN2 B cells is consistent with their status as precursors to antibody-secreting cells: they express higher levels of BLIMP-1 and IRF4, master transcription factors of ... WebJan 1, 2015 · Anaplastic large cell lymphoma (ALCL) is a distinct entity of T-cell lymphoma that can be divided into 2 subtypes based on the presence of translocations involving the ALK gene (ALK + and ALK − ALCL). The interferon regulatory factor 4 (IRF4) is known to be highly expressed in both ALK + and ALK − ALCLs. However, the role of IRF4 in the …

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WebThe IRF4/DUSP22 locus is rearranged in a newly recognized subtype of non-Hodgkin lymphoma, large B-cell lymphoma with IRF4 rearrangement. These lymphomas are uncommon, but are clinically distinct from morphologically similar lymphomas, including diffuse large B-cell lymphoma, high-grade follicular lymphoma, and pediatric-type … WebSep 29, 2024 · In vitro Stimulation of Human B Cells Generated Populations With Distinct IRF4 and Pax5 Expression Levels To evaluate PC differentiation in vitro at the transcription factor level, we next assessed the expression of IRF4 and Pax5.

WebInterferon regulatory factor 4 (IRF4) rearrangement is a common cytogenetic anomaly reported in various neoplastic lymphoproliferative disorders.IRF4 is a gene located on chromosome 6 that encodes for the IRF4 protein belonging to the IRF family of transcription factors. Large B-cell lymphoma with IRF4 rearrangement constitutes a novel provisional … WebAug 13, 2024 · Interferon regulatory factor 4 (IRF4) is a lymphoid transcription factor and a key regulator in the development of various immune cells, including T and B cells. It is well-known that IRF4 controls numerous decision-making processes relating to B cell …

WebSep 1, 2024 · Large B-cell lymphoma with IRF4 rearrangement (LBCL-IRF4) constitutes a novel provisional entity included in the classification of lymphoid tissue recently proposed by the WHO in its fourth revised edition.1 LBCL-IRF4 is a rare type of large B-cell lymphomas and accounts for 0.05% of cases. Literature reports it to be more common in children ... WebJul 23, 2024 · Analysis of IRF4 knockdown in naïve B cells revealed a similar knockdown level as that seen by nucleofection of purified naïve B cells (Figures 2, 7D) suggesting that this may be an alternate method for knockdown in naïve B cells. However, depending on the experimental outcome, sorting naïve B cells from nucleofected total B cells is ...

WebIRF-4 is a member of the interferon regulatory factor (IRF) family of transcription factors, which were first identified as being involved in the expression of interferon-induced genes. …

WebDec 10, 2024 · IRF4 is implicated in B cell malignancies, acting both as tumor suppressor and as tumor oncogene in different types of precursors and mature B cell neoplasia. Here, … i mean offWebOct 6, 2024 · Sustained IRF4 expression is sufficient to directly repress BCL-6 expression and promote plasma cell differentiation, which may reflect the dose-dependent function … i mean obviouslyWebApr 13, 2024 · The family/class of the large B-cell lymphomas (LBCL) in the 5th edition of the World Health Organization (WHO) classification of haematolymphoid tumors (WHO-HAEM5) features only a few major changes as compared to the 4th edition. In most entities, there are only subtle changes, many of them only representing some minor modifications in … i mean on youtube i mean on tabletWebApr 10, 2024 · Genetic classification helps to disclose molecular heterogeneity and therapeutic implications in diffuse large B-cell lymphoma (DLBCL). Using whole exome/genome sequencing, RNA-sequencing, and ... list of natural scot inhibitorsWebFeb 1, 2024 · ALK + large B-cell lymphomas typically express EMA, CD138, and IRF4/MUM1 but are negative for CD30 (in contrast with anaplastic large cell lymphoma cases) and notably negative to weakly positive for B-cell markers CD20, CD79a, and PAX5, as well as CD45. Finally, plasmablastic morphology in a large B-cell lymphoma should prompt … i mean oh my godWebJul 7, 2011 · Because deregulation of IRF4 expression by a t(6;14)(p25;q32) has already been described as a recurrent event in multiple myeloma 23 and because of the well-known function of IRF4 as transcription factor in B cells associated with oncogenic addiction, 24 we considered IRF4 to be the probable target of the translocation. ime anras