WebbShape-it is a shape-only rewrite of the original Pharao code that was developed in 2008 by Silicos (Jonatan Taminau, Gert Thijs and Hans De Winter ). It is based on the alignment method described by Grant and Pickup ( J. Phys. Chem. 1995, 99, 3503 ). WebbIn addition to the alignment information parsed by MakeDb.py to generate the initial database, CreateGermlines.py also requires the set of germline sequences that were used for the alignment passed to the -r argument. In the case of V-segment germlines, the reference sequences must be IMGT-gapped.
Update announcement of shape-it #chemoinformatics #RDKit …
Webb18 jan. 2024 · Now shape-it can be used from python. Here is a first example of cpyshapeit ;) cpyshapeit can not only calculate similarity score but also align molecule to reference … WebbWe highly recommend using SHAPEIT to infer the haplotypes underlying your study genotypes, then passing these to IMPUTE2 for imputation as shown in the second step of this example. Download IMPUTE2 IMPUTE2 is freely available for academic use. philippon the great reversal
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