Shoc2 uniprot

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August undefined, 2024

WebRCSB. monomer. 88-581. 1× MG; Assess. Structure of the human leucine rich repeat protein SHOC2, residues 80-582. 7tyg. WebUniProt accession no. Q9UQ13. shipped in. dry ice. storage temp. −20°C. Gene Information. human ... SHOC2(8036) ... SHOC2, together with protein phosphatase 1c (PP1c), forms a highly specific M-Ras effector complex and is essential for the activation of MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations ...

SHOC2 phosphatase-dependent RAF dimerization mediates

WebSHOC2 is predicted to structurally resemble the A subunit of PP2A and uses different regions to interact with MRAS/PP1 and SCRIB. ( A) Domain structure of the A subunit of … Web4 Feb 2024 · SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and … brian buffini events

SHOC2, CPTAC-1562 - CPTAC Assay Portal Office of Cancer …

Web22 Oct 2024 · Europe PMC is an archive of life sciences journal literature. WebUniProt website fallback message If you are not seeing anything on this page, it might be for multiple reasons: You might have JavaScript disabled: make sure to ... WebSoc-2 suppressor of clear homolog (SHOC2) is a gene that encodes a protein that functions in the RAS/ERK MAP kinase signaling pathway as a scaffold linking Ras to downstream … brian buffini pop by tags printable

Sur-8 antibody (17561-1-AP) Proteintech 武汉三鹰生物技术有限 …

Web8 Jul 2024 · Selfors et al. (1998) showed that soc2 encodes a protein composed almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. They identified a putative human homolog, SHOC2, which is 54% identical to soc2. They showed that SHOC2 mRNA was expressed in all tissues assayed and that the SHOC2 protein is … WebResearch studies have demonstrated that SHOC2 forms a complex with the catalytic subunit of the PP1 phosphatase and M-Ras, and this complex drives activation of Raf-ERK signaling in response to mitogenic growth factors (1). SHOC2 has also been shown to cross-talk with and activate the PI3K/Akt signaling axis through its interaction with the ... coupon code for inkstationWeb21 Mar 2024 · SHOC2 (SHOC2 Leucine Rich Repeat Scaffold Protein) is a Protein Coding gene. Diseases associated with SHOC2 include Noonan Syndrome-Like Disorder With … brian buffini real strengths

"WebSHOC2 leucine-rich repeat scaffold protein (HGNC Symbol) Entrez gene summary. ... Q9UQ13 (UniProt - Evidence at protein level) neXtProt. NX_Q9UQ13: Antibodypedia. SHOC2 antibodies: PROTEIN BROWSER. SHOC2-001. SHOC2-002. SHOC2-201. PROTEIN INFORMATION. Splice variant. UniProt. Protein class. Gene ontology. " - Shoc2 uniprot

Shoc2 uniprot

WebUniProt is a GBC global core biodata resource Main funding by: National Institutes of Health We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s … Web10 May 2024 · SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating RAF and MAPK-pathway activation by dephosphorylating a specific phosphoserine on RAF kinases. Here we present the high …

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WebWe use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. WebUniProt is a GBC global core biodata resource Main funding by: National Institutes of Health We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s …

WebSHOC2 Approved name SHOC2 leucine rich repeat scaffold protein Locus type gene with protein product HGNC ID HGNC:15454 Symbol status Approved Previous names soc-2 (suppressor of clear, C.elegans) homolog soc-2 suppressor of clear homolog (C. elegans) SHOC2 leucine-rich repeat scaffold protein SHOC2, leucine rich repeat scaffold protein WebSHOC2 10:110919367-111017307. Forward strand gene: SHOC2 leucine rich repeat scaffold protein Also known as: SUR8, SOC-2, SUR-8, SOC2, KIAA0862, ... Show more Source: UniProt. DECIPHER holds 10 sequence variants in this gene, in 10 open-access patients Overview

UniProt is a GBC global core biodata resource Main funding by: National Institutes of Health We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2024. See more This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. 1. Name1 2. See … See more WebWelcome to ProteomicsDB! ProteomicsDB is an effort of the Technische Universität München (TUM). It is dedicated to expedite the identification of the human proteome and its use across the scientific community.

WebDetect Leucine-rich repeat protein SHOC-2 using this rabbit polyclonal antibody, Anti-SHOC2 Antibody validated for use in western blotting & IHC. - Find MSDS or SDS, a COA, data sheets and more information. ... UniProt Number: Q9UQ13; Molecular Weight ~65 kDa observed. Uniprot describes 2 isoforms at ~60 kDa and ~65 kDa. Uncharacterized bands ...

Web16 Aug 2004 · UniProt is a GBC global core biodata resource Main funding by: National Institutes of Health We'd like to inform you that we have updated our Privacy Notice to … coupon code for incredibundlesWeb14 Dec 2024 · The SHOC2-MRAS-PP1C holophosphatase complex functions as a key regulator of RTK-RAS signalling by removing an inhibitory phosphorylation event on the … brian buffini pop by ideasWeb17561-1-AP targets Sur-8 in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. coupon code for indigo domestic flightsWebSHOC2 localizes to cytoplasm when inactive but rapidly translocates to the nucleus when activated, such as during growth factor stimulation. Thus, as expected, SHOC2 also participates in FGF receptor signaling. ... Uniprot describes 2 isoforms at ~60 kDa and ~65 kDa Uncharacterized bands may appear in some lysate(s). Physical form. brian buffini pathway to masteryWeb7 Nov 2013 · Search worldwide, life-sciences literature Search. Advanced Search coupon code for inogenWeb29 Sep 2024 · SHOC2 is as an essential scaffolding protein that engages both PP1C and RAS to dephosphorylate RAF NTpS 11-13 , but the structure of SHOC2 and the … brian buffini state of the marketWeb10 Jun 2024 · SHOC2 inhibition perturbs tumour growth in lung cancer models. To study the in vivo role of SHOC2 we have developed two mouse models of SHOC2 inactivation using Knock-out (KO) or Knock-in (KI ... coupon code for interstate studio