Slc11a1 rs7608307
WebSlc11a1 (formerly Nramp1) is a proton/divalent cation transporter that regulates cation homeostasis in macrophages. Slc11a2 mediates divalent cation uptake via the gut and delivery into cells. The mode of action of the two transporters remains controversial. Heterologous expression in frog oocytes shows Slc11a2 is a symporter, whereas Slc11a1 … Web(317) 888-8236. Pat. Five Star South 1195 N Madison Avenue Greenwood, IN 46142 E. of Greenwood Park Mall
Slc11a1 rs7608307
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WebJul 22, 2024 · SLC11A1 was identified as a proton cation antiporter, which localizes to lysosomes or late endosome. It has been reported that SLC11A1 regulates macrophage … WebFeb 9, 2024 · SLC11A1 is located in monocyte phagolysosomes that help to limit M. tuberculosis growth by transferring divalent cations across the membrane.
WebJan 15, 2024 · This study suggested that rs7573065 in SLC11A1 was associated with an increased risk and poor OS of prostate cancer. Our findings may provide evidence for genetic variants in autophagy-lysosome pathway as the risk and prognostic biomarkers for prostate cancer. WebApr 1, 2013 · SLC11A1 is a 90–100 kDa integral transmembrane protein expressed in the lysosomal compartment of macrophages and in tertiary granules of neutrophils. The human SLC11A1 gene was cloned, and localized to the long arm of chromosome 2 (2q35).
WebThis meta-analysis suggests that polymorphisms in the SLC11A1 gene contribute to TB (both PTB and EPTB), particularly in Asians. BACKGROUND Polymorphisms in SLC11A1 gene have been extensively studied for an association with tuberculosis (TB); however, results from replication studies have been inconsistent. OBJECTIVE To comprehensively … WebJul 22, 2024 · Although the relation of SLC11A1 polymorphisms with TB risk has been extensively studied, it has not been reported in the northwest Chinese Han population. …
WebMar 9, 2024 · The Slc11a1 encodes a late endosomal/lysosomal protein/divalent cation transporter, which regulates iron homeostasis in macrophages. results demonstrate a role for Slc11a1 (Nramp1) in modifying susceptibility to type 1 diabetes and illustrate that RNAi can be used to study causal genes in a mammalian model organism
WebDec 7, 2007 · Slc11a1 (formerly Nramp1) is a proton/divalent cation transporter that regulates cation homeostasis in macrophages. Slc11a2 mediates divalent cation uptake via the gut and delivery into cells. The mode of action of the two transporters remains controversial. Heterologous expression in frog oocytes s … building gcc from scratchWebSolute carrier family 11a member 1 (Slc11a1; formerly natural resistance-associated macrophage protein 1) encodes a late endosomal/lysosomal protein/divalent cation transporter, which regulates iron homeostasis in macrophages. During macrophage activation, Slc11a1 exerts pleiotropic effects on gene … building gccWebApr 15, 2013 · Solute carrier 11A1 (SLC11A1) is a divalent ion transporter formerly known as the natural resistance-associated macrophage protein (NRAMP1) and the Bcg/Lsh/Ity locus. SLC11A1 was thought to be exclusively expressed in monocyte/macrophages and to have roles in phagosome maturation and cell activation. building gates for wood fenceWebJan 25, 2011 · Background Natural resistance associated macrophage protein 1 (NRAMP1), encoded by the SLC11A1 gene, has been described to regulate macrophage activation and be associated with infectious and autoimmune diseases. The relation between SLC11A1 polymorphisms and tuberculosis susceptibility has been studied in different populations. … crown florals - parkersburgWebJan 1, 2009 · Slc11a1 enhanced Th1-mediated response to HEL immunization. Slc11a1 is proinflammatory, but it is not clear whether Slc11a1 directly affects the production of inflammatory cytokines by DCs and macrophages or through indirect activation of T-cells. Nevertheless, enhanced Th1 bias would accelerate autoimmune destruction in the … crown florals and giftsWebMar 21, 2024 · Decreased expression of the long non-coding RNA SLC7A11-AS1 predicts poor prognosis and promotes tumor growth in gastric cancer. (PMID: 29348845) Luo Y … crown florals coupon codeWebResults: (adjust pvalue < 0.01 and log FC ≥ 1). A cluster of 10 genes including CYBA, SLC11A1, FCER1G, ITGAM, ITGB2, CD53, ITGAX, VAMP8, CLEC5A,and CD300Awere found to be significant. crown flower drive